Larocaine powder CAS 553-63-9 is mainly used in laboratory Research and Development process and chemical and pharmaceutical production process. It is a local anesthetic with the chemical name N - [2- (methylamino) ethyl] -4-pyridylformamide or 2- (methylamino) ethyl-N - (4-pyridyl) formamide. It is a white to almost white powder. Its color may vary depending on its source and manufacturing method, and is essentially an analog of 2-methyl-4-pyridinecarboxylic acid (2-MP). Compared to other local anesthetics, it is a weak anesthetic that can be used to alleviate mild pain or itching. The melting point is 142-144 ° C. The melting point can be used as a factor for separately identifying purity and quality. It is a relatively stable compound. It is a low-dose local anesthetic widely used in some medical and research fields. However, Larocaine should be stored in a dry and cool place, avoiding direct light exposure. In addition, Larocaine reacts with acids, so mixing with fiber optic caustic soda should be avoided

The laboratory has accurately determined his chemical information, and the results are as follow:

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Addition information of chemical compound: Melting point 53.0 to 57.0 °C, Boiling point 421.21 ° C (rough estimate), Density 1.035, Refractive index 1.5290 (estimated), Acidity coefficient (PKA) 10.08 ± 0.25 (predicted), Steam pressure 1.01E-06mmHg at 25°C, Polarization: 32.9 10-24cm3, Surface tension: 40.1 dyne/cm, Enthalpy of evaporation: 65.48 kJ/mol.

The chemical synthesis of Larocaine powder mainly involves esterification reactions using phenylacetic acid and pyridine as raw materials, followed by stereoselective reduction and alkylation of the obtained esterification products to obtain Larocaine. The specific steps are as follows:

Reaction 1: Esterification reaction of phenylacetic acid and pyridine:

Firstly, phenylacetic acid and pyridine are mixed, and a catalyst dimethyl sulfoxide is added. The esterification reaction is carried out in an inert atmosphere using acetic acid or other solvents. After the reaction is complete, the product N-phenylacetylpyridine is obtained.

Reaction 2: Stereoselective reduction reaction:

Add N-phenylacetylpyridine to the mixture of alumina and acetonitrile, and then add a reducing agent for stereoselective reduction reaction to obtain the product N - (S) - phenylacetyl-4-phenylpiperid-2-one.

Reaction three: Alkylation reaction:

Add N - (S) - phenylacetyl-4-phenylpiperidine-2-one with excess propanol to a mixture of catalyst chromium trioxide and tryptophan acetate for alkylation reaction to obtain the target product N-propyl-4-phenylpiperidine-2-one (Larocaine).

Larcaine powder is an organic synthesis intermediate and pharmaceutical intermediate, which is mainly used in laboratory research and development process and chemical pharmaceutical production process. It is a synthetic cocaine analogue. In the 1930s, it was used as a local anesthetic in dentistry and ophthalmology, and as a dopamine uptake inhibitor. Therefore, it can not flow in the market, only for experimental purposes. White to yellow crystal, easy to change color, 2-8 ℃ storage for 10-15 days will become yellow. Larocaine is a local anesthetic. Its successor product is a local anesthetic preparation. Dimethocaine is often used as a local anesthetic in dentistry and ophthalmology. Therefore, it should be widely used in beauty and makeup. It is often used in hydrochloride form for ease of use. Inhalation: If inhaled, move victim to fresh air. Skin contact: Take off contaminated clothing and rinse skin thoroughly with soapy water and clean water. Seek medical advice if you feel unwell. Eye contact: separate eyelid and rinse with running water or normal saline. Seek immediate medical attention. Eat: gargle, do not vomit. Seek immediate medical attention.

1. Structure: The chemical structure of Larocaine consists of three parts: an aryl ring, an acrylic chain, and an imidazole group. The aryl ring is composed of a benzene ring and an amino group, the propylene chain contains two methoxy groups, and the imidazole group contains one nitrogen atom.

2. Solubility: Larocaine is soluble in organic solvents such as benzene and ethanol, and almost insoluble in water.

3. Chlorination reaction: Larocaine and chlorine will undergo substitution reaction, in which only one methoxy group will be replaced by chlorine. The product of this reaction is called monochromo Larocaine.

4. Stability: Larocaine is a relatively stable compound. It can be stored and transported at room temperature.

5. Biosynthesis: Larocaine is synthesized by the reaction of aniline, acrolein, and imidazole in the presence of HCl. The reaction product alkylates propylene and imidazole according to the Auger mechanism, ultimately producing Larocaine.

6. Polymer precursor: Larocaine has the characteristics of a polymer precursor. It can be used to prepare nano materials such as nanoparticles and nanotubes.

7. Other properties: Larocaine powder can also be used as a buffer in electrolytes and as a pain medication. In addition, it can also be used as an intermediate for organic materials.

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